Drug interactions
Calcium + Manganese
Severity: Minor
Calcium and Manganese: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Calcium can compete with manganese for intestinal absorption, and high calcium intake may reduce manganese uptake. This is mainly relevant for patients relying on supplements for manganese.
What this interaction means in plain words
Calcium and Manganese have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Calcium belongs to Gastrointestinal Tract; Manganese belongs to Gastrointestinal Tract.
Why it happens
Competition between divalent cations for intestinal absorption.
What to do
Take oral calcium and manganese supplements at least 2 hours apart.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Calcium
- Calcium + Ceftriaxone Contraindicated
- Acalabrutinib + Calcium Moderate
- Alendronate + Calcium Moderate
- Atazanavir + Calcium Moderate
- Baloxavir marboxil + Calcium Moderate
- Bendroflumethiazide + Calcium Moderate
Other interactions of Manganese
- Delafloxacin + Manganese Moderate
- Manganese + Omadacycline Moderate
- Manganese + Sarecycline Moderate
- Baloxavir marboxil + Manganese Minor
- Calcium acetate + Manganese Minor
- Calcium carbonate + Manganese Minor
Frequently asked questions
Can I take Calcium with Manganese?
MediHelp rates the interaction as minor. Calcium and Manganese have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Calcium can compete with manganese for intestinal absorption, and high calcium intake may reduce manganese uptake. This is mainly relevant for patients relying on supplements for manganese.
How serious is the interaction between Calcium and Manganese?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Take oral calcium and manganese supplements at least 2 hours apart.
What other medicines interact with Calcium?
MediHelp also lists interactions of Calcium with, for example, Ceftriaxone, Acalabrutinib, Alendronate. The full list is on the Calcium page.
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