Drug interactions
Calcium + Toremifene
Severity: Moderate
Calcium and Toremifene: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Toremifene may cause hypercalcemia, particularly in patients with bone metastases. Calcium supplements could add to the calcium load.
What this interaction means in plain words
Calcium and Toremifene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Calcium belongs to Gastrointestinal Tract; Toremifene belongs to Endocrine.
Why it happens
Toremifene can cause hypercalcemia, and supplemental calcium adds to calcium load; the interaction is pharmacodynamic.
What to do
Monitor serum calcium in patients receiving toremifene with calcium supplements. Stop supplements if hypercalcemia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Toremifene
- Amiodarone + Toremifene Contraindicated
- Dronedarone + Toremifene Contraindicated
- Nilotinib + Toremifene Contraindicated
- Pimozide + Toremifene Contraindicated
- Quinidine + Toremifene Contraindicated
- Ribociclib + Toremifene Contraindicated
Other interactions of Calcium
- Calcium + Ceftriaxone Contraindicated
- Acalabrutinib + Calcium Moderate
- Alendronate + Calcium Moderate
- Atazanavir + Calcium Moderate
- Baloxavir marboxil + Calcium Moderate
- Bendroflumethiazide + Calcium Moderate
Frequently asked questions
Can I take Calcium with Toremifene?
MediHelp rates the interaction as moderate. Calcium and Toremifene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Toremifene may cause hypercalcemia, particularly in patients with bone metastases. Calcium supplements could add to the calcium load.
How serious is the interaction between Calcium and Toremifene?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum calcium in patients receiving toremifene with calcium supplements. Stop supplements if hypercalcemia develops.
What other medicines interact with Toremifene?
MediHelp also lists interactions of Toremifene with, for example, Amiodarone, Dronedarone, Nilotinib. The full list is on the Toremifene page.
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