Drug interactions
Calcium carbonate + Chloroquine
Severity: Moderate
Calcium carbonate and Chloroquine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Antacids containing calcium can reduce chloroquine absorption, potentially lowering antimalarial or anti-inflammatory efficacy.
What this interaction means in plain words
Calcium carbonate and Chloroquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Calcium carbonate belongs to Gastrointestinal Tract; Chloroquine belongs to Anti Parasitic.
Why it happens
Cations and antacids reduce gastrointestinal absorption of chloroquine.
What to do
Give chloroquine at least 4 hours apart from calcium carbonate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Calcium carbonate
Other interactions of Chloroquine
- Chloroquine + Cisapride Contraindicated
- Chloroquine + Dofetilide Contraindicated
- Chloroquine + Dronedarone Contraindicated
- Chloroquine + Droperidol Contraindicated
- Chloroquine + Panobinostat Contraindicated
- Chloroquine + Pimozide Contraindicated
Frequently asked questions
Can I take Calcium carbonate with Chloroquine?
MediHelp rates the interaction as moderate. Calcium carbonate and Chloroquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Antacids containing calcium can reduce chloroquine absorption, potentially lowering antimalarial or anti-inflammatory efficacy.
How serious is the interaction between Calcium carbonate and Chloroquine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give chloroquine at least 4 hours apart from calcium carbonate.
What other medicines interact with Calcium carbonate?
MediHelp also lists interactions of Calcium carbonate with, for example, Acalabrutinib, Alendronate, Amlodipine-hydrochlorothiazide-valsartan. The full list is on the Calcium carbonate page.
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