Drug interactions
Calcium carbonate + Digoxin
Severity: Moderate
Calcium carbonate and Digoxin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Antacids may modestly reduce digoxin absorption when taken together. The effect is usually small, though reduced digoxin levels could matter in patients with a narrow margin of control. Hypercalcemia from high calcium intake can also increase digoxin toxicity.
What this interaction means in plain words
Calcium carbonate and Digoxin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Calcium carbonate belongs to Gastrointestinal Tract; Digoxin belongs to Cardiovascular.
Why it happens
Binding or adsorption of digoxin in the gut reduces absorption, and hypercalcemia sensitizes the myocardium to digoxin.
What to do
Separate digoxin and calcium carbonate by at least 2 hours. Monitor digoxin levels, serum calcium and heart rate or rhythm if high doses of calcium are used.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Calcium carbonate
Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Frequently asked questions
Can I take Calcium carbonate with Digoxin?
MediHelp rates the interaction as moderate. Calcium carbonate and Digoxin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Antacids may modestly reduce digoxin absorption when taken together. The effect is usually small, though reduced digoxin levels could matter in patients with a narrow margin of control. Hypercalcemia from high calcium intake can also increase digoxin toxicity.
How serious is the interaction between Calcium carbonate and Digoxin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Separate digoxin and calcium carbonate by at least 2 hours. Monitor digoxin levels, serum calcium and heart rate or rhythm if high doses of calcium are used.
What other medicines interact with Calcium carbonate?
MediHelp also lists interactions of Calcium carbonate with, for example, Acalabrutinib, Alendronate, Amlodipine-hydrochlorothiazide-valsartan. The full list is on the Calcium carbonate page.
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