Drug interactions
Calcium carbonate + Dolutegravir
Severity: Moderate
Calcium carbonate and Dolutegravir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Calcium carbonate binds dolutegravir in the gut and lowers its absorption, which can reduce antiviral exposure. This risks virologic failure and resistance if doses are taken together while fasting.
What this interaction means in plain words
Calcium carbonate and Dolutegravir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Calcium carbonate belongs to Gastrointestinal Tract; Dolutegravir belongs to Anti Virals.
Why it happens
Chelation of dolutegravir by calcium cations in the gastrointestinal tract reduces absorption.
What to do
Give dolutegravir 2 hours before or 6 hours after calcium carbonate. Alternatively, take both together with food.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Calcium carbonate
Other interactions of Dolutegravir
Frequently asked questions
Can I take Calcium carbonate with Dolutegravir?
MediHelp rates the interaction as moderate. Calcium carbonate and Dolutegravir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Calcium carbonate binds dolutegravir in the gut and lowers its absorption, which can reduce antiviral exposure. This risks virologic failure and resistance if doses are taken together while fasting.
How serious is the interaction between Calcium carbonate and Dolutegravir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give dolutegravir 2 hours before or 6 hours after calcium carbonate. Alternatively, take both together with food.
What other medicines interact with Calcium carbonate?
MediHelp also lists interactions of Calcium carbonate with, for example, Acalabrutinib, Alendronate, Amlodipine-hydrochlorothiazide-valsartan. The full list is on the Calcium carbonate page.
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