Drug interactions
Calcium carbonate + Hydrochlorothiazide-irbesartan
Severity: Moderate
Calcium carbonate and Hydrochlorothiazide-irbesartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazides reduce urinary calcium loss, and with calcium supplements this can lead to hypercalcemia and, rarely, milk-alkali syndrome. Risk is higher with large doses or renal impairment.
What this interaction means in plain words
Calcium carbonate and Hydrochlorothiazide-irbesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Calcium carbonate belongs to Gastrointestinal Tract; Hydrochlorothiazide-irbesartan belongs to Cardiovascular.
Why it happens
Thiazides increase distal tubular calcium reabsorption, adding to calcium load from supplementation.
What to do
Monitor serum calcium, particularly with high-dose supplements or renal impairment. Reduce the calcium dose if hypercalcemia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-irbesartan
- Aliskiren + Hydrochlorothiazide-irbesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-irbesartan Contraindicated
- Hydrochlorothiazide-irbesartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-irbesartan Major
- Amifostine + Hydrochlorothiazide-irbesartan Major
- Amiloride + Hydrochlorothiazide-irbesartan Major
Other interactions of Calcium carbonate
Frequently asked questions
Can I take Calcium carbonate with Hydrochlorothiazide-irbesartan?
MediHelp rates the interaction as moderate. Calcium carbonate and Hydrochlorothiazide-irbesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thiazides reduce urinary calcium loss, and with calcium supplements this can lead to hypercalcemia and, rarely, milk-alkali syndrome. Risk is higher with large doses or renal impairment.
How serious is the interaction between Calcium carbonate and Hydrochlorothiazide-irbesartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum calcium, particularly with high-dose supplements or renal impairment. Reduce the calcium dose if hypercalcemia develops.
What other medicines interact with Hydrochlorothiazide-irbesartan?
MediHelp also lists interactions of Hydrochlorothiazide-irbesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-irbesartan page.
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