Drug interactions
Calcium carbonate + Metolazone
Severity: Moderate
Calcium carbonate and Metolazone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metolazone reduces urinary calcium excretion, and combined with calcium carbonate it may cause hypercalcemia. Large alkali doses can add metabolic alkalosis.
What this interaction means in plain words
Calcium carbonate and Metolazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Calcium carbonate belongs to Gastrointestinal Tract; Metolazone belongs to Cardiovascular.
Why it happens
Enhanced distal tubular calcium reabsorption adds to calcium load from the supplement.
What to do
Monitor serum calcium and acid-base status, and reduce calcium dose if hypercalcemia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Calcium carbonate
Other interactions of Metolazone
Frequently asked questions
Can I take Calcium carbonate with Metolazone?
MediHelp rates the interaction as moderate. Calcium carbonate and Metolazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Metolazone reduces urinary calcium excretion, and combined with calcium carbonate it may cause hypercalcemia. Large alkali doses can add metabolic alkalosis.
How serious is the interaction between Calcium carbonate and Metolazone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum calcium and acid-base status, and reduce calcium dose if hypercalcemia develops.
What other medicines interact with Calcium carbonate?
MediHelp also lists interactions of Calcium carbonate with, for example, Acalabrutinib, Alendronate, Amlodipine-hydrochlorothiazide-valsartan. The full list is on the Calcium carbonate page.
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