Drug interactions
Calcium gluconate + Hydrochlorothiazide
Severity: Moderate
Calcium gluconate and Hydrochlorothiazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazide diuretics reduce urinary calcium loss, so added calcium can accumulate and cause hypercalcemia. The risk is greater with large or intravenous calcium doses, renal impairment, or concurrent vitamin D.
What this interaction means in plain words
Calcium gluconate and Hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Calcium gluconate belongs to Gastrointestinal Tract; Hydrochlorothiazide belongs to Cardiovascular.
Why it happens
Thiazides increase distal tubular calcium reabsorption, lowering renal calcium excretion.
What to do
Monitor serum calcium when calcium gluconate is given repeatedly or at high doses with hydrochlorothiazide, and lower the calcium dose if levels rise.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide
Other interactions of Calcium gluconate
- Calcium gluconate + Ceftriaxone Contraindicated
- Calcium gluconate + Digoxin Major
- Alendronate + Calcium gluconate Moderate
- Amlodipine-atorvastatin + Calcium gluconate Moderate
- Amlodipine-hydrochlorothiazide-valsartan + Calcium gluconate Moderate
- Amlodipine-olmesartan-hydrochlorothiazide + Calcium gluconate Moderate
Frequently asked questions
Can I take Calcium gluconate with Hydrochlorothiazide?
MediHelp rates the interaction as moderate. Calcium gluconate and Hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thiazide diuretics reduce urinary calcium loss, so added calcium can accumulate and cause hypercalcemia. The risk is greater with large or intravenous calcium doses, renal impairment, or concurrent vitamin D.
How serious is the interaction between Calcium gluconate and Hydrochlorothiazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum calcium when calcium gluconate is given repeatedly or at high doses with hydrochlorothiazide, and lower the calcium dose if levels rise.
What other medicines interact with Hydrochlorothiazide?
MediHelp also lists interactions of Hydrochlorothiazide with, for example, Dofetilide, Amifostine, Amiodarone. The full list is on the Hydrochlorothiazide page.
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