Drug interactions
Calcium gluconate + Vitamin d
Severity: Moderate
Calcium gluconate and Vitamin d: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vitamin D increases intestinal calcium absorption, so combining it with calcium salts is often intended but can raise serum calcium too far in some patients. Hypercalcemia may cause nausea, polyuria, confusion, kidney injury and arrhythmias, especially with high doses or renal impairment.
What this interaction means in plain words
Calcium gluconate and Vitamin d can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Calcium gluconate belongs to Gastrointestinal Tract; Vitamin d belongs to Gastrointestinal Tract.
Why it happens
Vitamin D metabolites enhance intestinal calcium absorption, producing additive increases in serum calcium.
What to do
Monitor serum calcium and renal function periodically, particularly in renal impairment or with high doses. Reduce the calcium or vitamin D dose if hypercalcemia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vitamin d
Other interactions of Calcium gluconate
- Calcium gluconate + Ceftriaxone Contraindicated
- Calcium gluconate + Digoxin Major
- Alendronate + Calcium gluconate Moderate
- Amlodipine-atorvastatin + Calcium gluconate Moderate
- Amlodipine-hydrochlorothiazide-valsartan + Calcium gluconate Moderate
- Amlodipine-olmesartan-hydrochlorothiazide + Calcium gluconate Moderate
Frequently asked questions
Can I take Calcium gluconate with Vitamin d?
MediHelp rates the interaction as moderate. Calcium gluconate and Vitamin d can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vitamin D increases intestinal calcium absorption, so combining it with calcium salts is often intended but can raise serum calcium too far in some patients. Hypercalcemia may cause nausea, polyuria, confusion, kidney injury and arrhythmias, especially with high doses or renal impairment.
How serious is the interaction between Calcium gluconate and Vitamin d?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum calcium and renal function periodically, particularly in renal impairment or with high doses. Reduce the calcium or vitamin D dose if hypercalcemia develops.
What other medicines interact with Vitamin d?
MediHelp also lists interactions of Vitamin d with, for example, Aluminum hydroxide, Amlodipine-hydrochlorothiazide-valsartan, Amlodipine-olmesartan-hydrochlorothiazide. The full list is on the Vitamin d page.
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