Drug interactions
Canagliflozin + Carbamazepine
Severity: Moderate
Canagliflozin and Carbamazepine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
UGT inducers such as carbamazepine lower canagliflozin exposure, which may weaken glycemic control.
What this interaction means in plain words
Canagliflozin and Carbamazepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Canagliflozin belongs to Endocrine; Carbamazepine belongs to Central Nervous System.
Why it happens
Carbamazepine induces UGT enzymes, increasing canagliflozin glucuronidation and clearance.
What to do
Monitor glycemic control. If control is inadequate and renal function allows (eGFR above 60), consider increasing canagliflozin to 300 mg daily, otherwise use another agent.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Carbamazepine
- Artemether / lumefantrine + Carbamazepine Contraindicated
- Cabotegravir + Carbamazepine Contraindicated
- Carbamazepine + Delamanid Contraindicated
- Carbamazepine + Dienogest / estradiol valerate Contraindicated
- Carbamazepine + Doravirine Contraindicated
- Carbamazepine + Elbasvir / grazoprevir Contraindicated
Other interactions of Canagliflozin
Frequently asked questions
Can I take Canagliflozin with Carbamazepine?
MediHelp rates the interaction as moderate. Canagliflozin and Carbamazepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. UGT inducers such as carbamazepine lower canagliflozin exposure, which may weaken glycemic control.
How serious is the interaction between Canagliflozin and Carbamazepine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glycemic control. If control is inadequate and renal function allows (eGFR above 60), consider increasing canagliflozin to 300 mg daily, otherwise use another agent.
What other medicines interact with Carbamazepine?
MediHelp also lists interactions of Carbamazepine with, for example, Artemether / lumefantrine, Cabotegravir, Delamanid. The full list is on the Carbamazepine page.
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