Drug interactions
Canagliflozin + Eplerenone
Severity: Moderate
Canagliflozin and Eplerenone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Canagliflozin has been associated with small increases in serum potassium in some patients, particularly with renal impairment or other potassium-raising drugs. Combined with eplerenone, hyperkalemia may become more likely, though the effect is generally modest.
What this interaction means in plain words
Canagliflozin and Eplerenone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Canagliflozin belongs to Endocrine; Eplerenone belongs to Cardiovascular.
Why it happens
Possible additive potassium elevation; canagliflozin effect likely via volume depletion and reduced renal function.
What to do
Monitor serum potassium and renal function periodically, especially in patients with reduced eGFR.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eplerenone
- Amiloride + Eplerenone Contraindicated
- Atazanavir + Eplerenone Contraindicated
- Clarithromycin + Eplerenone Contraindicated
- Cobicistat + Eplerenone Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Eplerenone Contraindicated
- Ensitrelvir + Eplerenone Contraindicated
Other interactions of Canagliflozin
Frequently asked questions
Can I take Canagliflozin with Eplerenone?
MediHelp rates the interaction as moderate. Canagliflozin and Eplerenone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Canagliflozin has been associated with small increases in serum potassium in some patients, particularly with renal impairment or other potassium-raising drugs. Combined with eplerenone, hyperkalemia may become more likely, though the effect is generally modest.
How serious is the interaction between Canagliflozin and Eplerenone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and renal function periodically, especially in patients with reduced eGFR.
What other medicines interact with Eplerenone?
MediHelp also lists interactions of Eplerenone with, for example, Amiloride, Atazanavir, Clarithromycin. The full list is on the Eplerenone page.
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