Drug interactions
Canagliflozin + Losartan
Severity: Moderate
Canagliflozin and Losartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Canagliflozin can cause volume depletion and hypotension, and it may modestly raise potassium in some patients. Combined with losartan, there is a higher risk of low blood pressure and acute kidney injury, and a potassium rise is possible.
What this interaction means in plain words
Canagliflozin and Losartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Canagliflozin belongs to Endocrine; Losartan belongs to Cardiovascular.
Why it happens
SGLT2-mediated osmotic diuresis and volume contraction add to angiotensin receptor blockade effects on renal hemodynamics and potassium handling.
What to do
Check volume status, renal function and potassium after starting canagliflozin. Reduce diuretic doses if needed and counsel on hydration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Losartan
- Aliskiren + Losartan Contraindicated
- Losartan + Sparsentan Contraindicated
- Amifostine + Losartan Major
- Amiloride + Losartan Major
- Amlodipine-benazepril + Losartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Losartan Major
Other interactions of Canagliflozin
Frequently asked questions
Can I take Canagliflozin with Losartan?
MediHelp rates the interaction as moderate. Canagliflozin and Losartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Canagliflozin can cause volume depletion and hypotension, and it may modestly raise potassium in some patients. Combined with losartan, there is a higher risk of low blood pressure and acute kidney injury, and a potassium rise is possible.
How serious is the interaction between Canagliflozin and Losartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check volume status, renal function and potassium after starting canagliflozin. Reduce diuretic doses if needed and counsel on hydration.
What other medicines interact with Losartan?
MediHelp also lists interactions of Losartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Losartan page.
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