Drug interactions
Canagliflozin + Trimethoprim
Severity: Moderate
Canagliflozin and Trimethoprim: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trimethoprim blocks epithelial sodium channels and can cause hyperkalemia, especially in renal impairment. Canagliflozin may modestly add to potassium elevation.
What this interaction means in plain words
Canagliflozin and Trimethoprim can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Canagliflozin belongs to Endocrine; Trimethoprim belongs to Anti Bacterial.
Why it happens
Additive effects on potassium: trimethoprim inhibits distal sodium channels, reducing potassium excretion.
What to do
Monitor serum potassium and renal function during combined use, particularly with prolonged or high-dose trimethoprim.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Canagliflozin
Other interactions of Trimethoprim
Frequently asked questions
Can I take Canagliflozin with Trimethoprim?
MediHelp rates the interaction as moderate. Canagliflozin and Trimethoprim can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trimethoprim blocks epithelial sodium channels and can cause hyperkalemia, especially in renal impairment. Canagliflozin may modestly add to potassium elevation.
How serious is the interaction between Canagliflozin and Trimethoprim?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and renal function during combined use, particularly with prolonged or high-dose trimethoprim.
What other medicines interact with Canagliflozin?
MediHelp also lists interactions of Canagliflozin with, for example, Aliskiren, Amiloride, Amlodipine-benazepril. The full list is on the Canagliflozin page.
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