Drug interactions
Canagliflozin-metformin + Dofetilide
Severity: Moderate
Canagliflozin-metformin and Dofetilide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dofetilide is a cation secreted by renal tubular transporters and may compete with metformin for elimination, raising metformin levels. Metformin accumulation raises the risk of lactic acidosis, particularly with reduced renal function.
What this interaction means in plain words
Canagliflozin-metformin and Dofetilide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Canagliflozin-metformin belongs to Endocrine; Dofetilide belongs to Cardiovascular.
Why it happens
Competition for renal tubular cation secretion (OCT2/MATE) may reduce metformin clearance.
What to do
Monitor renal function and for signs of metformin excess; consider a metformin dose reduction if renal function is impaired.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Canagliflozin-metformin
Other interactions of Dofetilide
- Amiodarone + Dofetilide Contraindicated
- Amisulpride + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Candesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
Frequently asked questions
Can I take Canagliflozin-metformin with Dofetilide?
MediHelp rates the interaction as moderate. Canagliflozin-metformin and Dofetilide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dofetilide is a cation secreted by renal tubular transporters and may compete with metformin for elimination, raising metformin levels. Metformin accumulation raises the risk of lactic acidosis, particularly with reduced renal function.
How serious is the interaction between Canagliflozin-metformin and Dofetilide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function and for signs of metformin excess; consider a metformin dose reduction if renal function is impaired.
What other medicines interact with Canagliflozin-metformin?
MediHelp also lists interactions of Canagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Canagliflozin-metformin page.
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