Drug interactions
Canakinumab + Lomustine
Severity: Moderate
Canakinumab and Lomustine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Canakinumab blocks interleukin-1 beta and increases infection risk, while lomustine causes myelosuppression. Together the risk of serious infections may be greater, and signs of infection can be blunted.
What this interaction means in plain words
Canakinumab and Lomustine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Canakinumab belongs to Miscellaneous; Lomustine belongs to Oncology.
Why it happens
Additive immunosuppression from IL-1 beta blockade and cytotoxic bone marrow suppression.
What to do
Monitor blood counts and screen for infection promptly. Hold canakinumab if a serious infection develops or neutropenia is severe.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lomustine
- Adenovirus types 4 and 7 live + Lomustine Contraindicated
- Bcg vaccine live + Lomustine Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Lomustine Contraindicated
- Lomustine + Measles mumps and rubella vaccine Contraindicated
- Lomustine + Measles mumps and rubella vaccine live Contraindicated
- Lomustine + Measles mumps rubella and varicella vaccine live Contraindicated
Other interactions of Canakinumab
- Adalimumab + Canakinumab Major
- Anakinra + Canakinumab Major
- Baricitinib + Canakinumab Major
- Basiliximab + Canakinumab Major
- Canakinumab + Etanercept Major
- Canakinumab + Golimumab Major
Frequently asked questions
Can I take Canakinumab with Lomustine?
MediHelp rates the interaction as moderate. Canakinumab and Lomustine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Canakinumab blocks interleukin-1 beta and increases infection risk, while lomustine causes myelosuppression. Together the risk of serious infections may be greater, and signs of infection can be blunted.
How serious is the interaction between Canakinumab and Lomustine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and screen for infection promptly. Hold canakinumab if a serious infection develops or neutropenia is severe.
What other medicines interact with Lomustine?
MediHelp also lists interactions of Lomustine with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Lomustine page.
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