Drug interactions
Capivasertib + Posaconazole
Severity: Major
Capivasertib and Posaconazole: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Posaconazole may increase capivasertib concentrations since capivasertib is metabolized by CYP3A4. This can heighten adverse effects such as hyperglycemia, diarrhea, rash and mucosal toxicity.
What this interaction means in plain words
Capivasertib and Posaconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Capivasertib belongs to Oncology; Posaconazole belongs to Anti Fungals.
Why it happens
Strong CYP3A4 inhibition by posaconazole decreases capivasertib metabolism.
What to do
Avoid the combination where possible. If it is needed, reduce the capivasertib dose per labeling and monitor glucose and tolerability.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Other interactions of Capivasertib
Frequently asked questions
Can I take Capivasertib with Posaconazole?
MediHelp rates the interaction as major. Capivasertib and Posaconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Posaconazole may increase capivasertib concentrations since capivasertib is metabolized by CYP3A4. This can heighten adverse effects such as hyperglycemia, diarrhea, rash and mucosal toxicity.
How serious is the interaction between Capivasertib and Posaconazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible. If it is needed, reduce the capivasertib dose per labeling and monitor glucose and tolerability.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
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