Drug interactions
Capmatinib + Melatonin
Severity: Minor
Capmatinib and Melatonin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Capmatinib is a weak CYP1A2 inhibitor, and melatonin is cleared mainly by CYP1A2. Melatonin exposure may rise modestly, increasing next-day drowsiness.
What this interaction means in plain words
Capmatinib and Melatonin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Capmatinib belongs to Oncology; Melatonin belongs to Gastrointestinal Tract.
Why it happens
Inhibition of CYP1A2-mediated melatonin metabolism by capmatinib.
What to do
Start melatonin at a low dose and reduce it if daytime sedation develops.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Melatonin
- Fluvoxamine + Melatonin Major
- Alfentanil + Melatonin Moderate
- Belladonna and opium + Melatonin Moderate
- Buprenorphine buccal + Melatonin Moderate
- Butabarbital + Melatonin Moderate
- Butalbital + Melatonin Moderate
Other interactions of Capmatinib
- Amobarbital + Capmatinib Major
- Apalutamide + Capmatinib Major
- Capmatinib + Carbamazepine Major
- Capmatinib + Efavirenz Major
- Capmatinib + Enzalutamide Major
- Capmatinib + Phenytoin Major
Frequently asked questions
Can I take Capmatinib with Melatonin?
MediHelp rates the interaction as minor. Capmatinib and Melatonin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Capmatinib is a weak CYP1A2 inhibitor, and melatonin is cleared mainly by CYP1A2. Melatonin exposure may rise modestly, increasing next-day drowsiness.
How serious is the interaction between Capmatinib and Melatonin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start melatonin at a low dose and reduce it if daytime sedation develops.
What other medicines interact with Melatonin?
MediHelp also lists interactions of Melatonin with, for example, Fluvoxamine, Alfentanil, Belladonna and opium. The full list is on the Melatonin page.
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