Drug interactions
Captopril-hydrochlorothiazide + Chlorpromazine
Severity: Moderate
Captopril-hydrochlorothiazide and Chlorpromazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorpromazine has alpha-adrenergic blocking activity that can lower blood pressure, and this adds to the antihypertensive effect of captopril and hydrochlorothiazide. Patients may develop orthostatic hypotension, dizziness or falls, particularly when starting treatment or raising doses.
What this interaction means in plain words
Captopril-hydrochlorothiazide and Chlorpromazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Captopril-hydrochlorothiazide belongs to Cardiovascular; Chlorpromazine belongs to Central Nervous System.
Why it happens
Additive hypotensive effects from alpha-1 adrenergic blockade by chlorpromazine and ACE inhibition plus diuresis from the combination product.
What to do
Monitor blood pressure and orthostatic symptoms when starting or adjusting either drug. Reduce the antihypertensive dose if symptomatic hypotension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Captopril-hydrochlorothiazide
- Aliskiren + Captopril-hydrochlorothiazide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aceclofenac + Captopril-hydrochlorothiazide Major
- Aldesleukin + Captopril-hydrochlorothiazide Major
- Amifostine + Captopril-hydrochlorothiazide Major
Other interactions of Chlorpromazine
- Chlorpromazine + Dofetilide Contraindicated
- Chlorpromazine + Dronedarone Contraindicated
- Chlorpromazine + Droperidol Contraindicated
- Chlorpromazine + Ibutilide Contraindicated
- Chlorpromazine + Metrizamide Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
Frequently asked questions
Can I take Captopril-hydrochlorothiazide with Chlorpromazine?
MediHelp rates the interaction as moderate. Captopril-hydrochlorothiazide and Chlorpromazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chlorpromazine has alpha-adrenergic blocking activity that can lower blood pressure, and this adds to the antihypertensive effect of captopril and hydrochlorothiazide. Patients may develop orthostatic hypotension, dizziness or falls, particularly when starting treatment or raising doses.
How serious is the interaction between Captopril-hydrochlorothiazide and Chlorpromazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms when starting or adjusting either drug. Reduce the antihypertensive dose if symptomatic hypotension develops.
What other medicines interact with Captopril-hydrochlorothiazide?
MediHelp also lists interactions of Captopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sacubitril / valsartan. The full list is on the Captopril-hydrochlorothiazide page.
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