Drug interactions
Captopril-hydrochlorothiazide + Lisdexamfetamine
Severity: Moderate
Captopril-hydrochlorothiazide and Lisdexamfetamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lisdexamfetamine is a sympathomimetic that can raise blood pressure and heart rate, potentially reducing the antihypertensive effect of captopril and hydrochlorothiazide. Loss of blood pressure control may occur in treated hypertensive patients.
What this interaction means in plain words
Captopril-hydrochlorothiazide and Lisdexamfetamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Captopril-hydrochlorothiazide belongs to Cardiovascular; Lisdexamfetamine belongs to Central Nervous System.
Why it happens
Amphetamine-induced norepinephrine release causes vasoconstriction and increased cardiac output, opposing antihypertensive effects.
What to do
Monitor blood pressure and heart rate regularly after starting or changing lisdexamfetamine. Adjust antihypertensive therapy if control is lost.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Captopril-hydrochlorothiazide
- Aliskiren + Captopril-hydrochlorothiazide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aceclofenac + Captopril-hydrochlorothiazide Major
- Aldesleukin + Captopril-hydrochlorothiazide Major
- Amifostine + Captopril-hydrochlorothiazide Major
Other interactions of Lisdexamfetamine
- Isocarboxazid + Lisdexamfetamine Contraindicated
- Linezolid + Lisdexamfetamine Contraindicated
- Lisdexamfetamine + Phenelzine Contraindicated
- Lisdexamfetamine + Procarbazine Contraindicated
- Lisdexamfetamine + Rasagiline Contraindicated
- Lisdexamfetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Captopril-hydrochlorothiazide with Lisdexamfetamine?
MediHelp rates the interaction as moderate. Captopril-hydrochlorothiazide and Lisdexamfetamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lisdexamfetamine is a sympathomimetic that can raise blood pressure and heart rate, potentially reducing the antihypertensive effect of captopril and hydrochlorothiazide. Loss of blood pressure control may occur in treated hypertensive patients.
How serious is the interaction between Captopril-hydrochlorothiazide and Lisdexamfetamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate regularly after starting or changing lisdexamfetamine. Adjust antihypertensive therapy if control is lost.
What other medicines interact with Captopril-hydrochlorothiazide?
MediHelp also lists interactions of Captopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sacubitril / valsartan. The full list is on the Captopril-hydrochlorothiazide page.
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