Drug interactions
Captopril-hydrochlorothiazide + Prochlorperazine
Severity: Minor
Captopril-hydrochlorothiazide and Prochlorperazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Prochlorperazine can cause orthostatic hypotension through alpha-adrenergic blockade. With an ACE inhibitor and thiazide, blood pressure reduction may be greater, raising the risk of dizziness and falls.
What this interaction means in plain words
Captopril-hydrochlorothiazide and Prochlorperazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Captopril-hydrochlorothiazide belongs to Cardiovascular; Prochlorperazine belongs to Central Nervous System.
Why it happens
Additive hypotensive effects from alpha-adrenergic blockade combined with ACE inhibition and diuresis.
What to do
Monitor blood pressure and orthostatic symptoms, especially in older patients. Lower the antihypertensive dose if hypotension occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Captopril-hydrochlorothiazide
- Aliskiren + Captopril-hydrochlorothiazide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aceclofenac + Captopril-hydrochlorothiazide Major
- Aldesleukin + Captopril-hydrochlorothiazide Major
- Amifostine + Captopril-hydrochlorothiazide Major
Other interactions of Prochlorperazine
- Dronedarone + Prochlorperazine Contraindicated
- Ibutilide + Prochlorperazine Contraindicated
- Nilotinib + Prochlorperazine Contraindicated
- Pimozide + Prochlorperazine Contraindicated
- Prochlorperazine + Thioridazine Contraindicated
- Amiodarone + Prochlorperazine Major
Frequently asked questions
Can I take Captopril-hydrochlorothiazide with Prochlorperazine?
MediHelp rates the interaction as minor. Captopril-hydrochlorothiazide and Prochlorperazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Prochlorperazine can cause orthostatic hypotension through alpha-adrenergic blockade. With an ACE inhibitor and thiazide, blood pressure reduction may be greater, raising the risk of dizziness and falls.
How serious is the interaction between Captopril-hydrochlorothiazide and Prochlorperazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms, especially in older patients. Lower the antihypertensive dose if hypotension occurs.
What other medicines interact with Captopril-hydrochlorothiazide?
MediHelp also lists interactions of Captopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sacubitril / valsartan. The full list is on the Captopril-hydrochlorothiazide page.
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