Drug interactions
Captopril-hydrochlorothiazide + Propofol
Severity: Moderate
Captopril-hydrochlorothiazide and Propofol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Propofol causes vasodilation and myocardial depression, and patients on ACE inhibitors and diuretics may experience more pronounced hypotension during anesthesia induction.
What this interaction means in plain words
Captopril-hydrochlorothiazide and Propofol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Captopril-hydrochlorothiazide belongs to Cardiovascular; Propofol belongs to Central Nervous System.
Why it happens
Additive hypotensive effects from anesthetic vasodilation and renin-angiotensin blockade with volume depletion.
What to do
Inform the anesthesia team and monitor blood pressure continuously. Be ready to give fluids or vasopressors and consider holding the ACE inhibitor and diuretic before surgery per local protocol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Captopril-hydrochlorothiazide
- Aliskiren + Captopril-hydrochlorothiazide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aceclofenac + Captopril-hydrochlorothiazide Major
- Aldesleukin + Captopril-hydrochlorothiazide Major
- Amifostine + Captopril-hydrochlorothiazide Major
Other interactions of Propofol
Frequently asked questions
Can I take Captopril-hydrochlorothiazide with Propofol?
MediHelp rates the interaction as moderate. Captopril-hydrochlorothiazide and Propofol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Propofol causes vasodilation and myocardial depression, and patients on ACE inhibitors and diuretics may experience more pronounced hypotension during anesthesia induction.
How serious is the interaction between Captopril-hydrochlorothiazide and Propofol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Inform the anesthesia team and monitor blood pressure continuously. Be ready to give fluids or vasopressors and consider holding the ACE inhibitor and diuretic before surgery per local protocol.
What other medicines interact with Captopril-hydrochlorothiazide?
MediHelp also lists interactions of Captopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sacubitril / valsartan. The full list is on the Captopril-hydrochlorothiazide page.
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