Drug interactions
Captopril-hydrochlorothiazide + Toremifene
Severity: Moderate
Captopril-hydrochlorothiazide and Toremifene: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazides reduce urinary calcium excretion, and toremifene can cause hypercalcemia, particularly in patients with bone metastases. Combined use may raise serum calcium further.
What this interaction means in plain words
Captopril-hydrochlorothiazide and Toremifene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Captopril-hydrochlorothiazide belongs to Cardiovascular; Toremifene belongs to Endocrine.
Why it happens
Thiazide-reduced renal calcium excretion adds to toremifene-associated hypercalcemia.
What to do
Monitor serum calcium during the first weeks of therapy and consider an alternative to the thiazide if hypercalcemia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Captopril-hydrochlorothiazide
- Aliskiren + Captopril-hydrochlorothiazide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aceclofenac + Captopril-hydrochlorothiazide Major
- Aldesleukin + Captopril-hydrochlorothiazide Major
- Amifostine + Captopril-hydrochlorothiazide Major
Other interactions of Toremifene
- Amiodarone + Toremifene Contraindicated
- Dronedarone + Toremifene Contraindicated
- Nilotinib + Toremifene Contraindicated
- Pimozide + Toremifene Contraindicated
- Quinidine + Toremifene Contraindicated
- Ribociclib + Toremifene Contraindicated
Frequently asked questions
Can I take Captopril-hydrochlorothiazide with Toremifene?
MediHelp rates the interaction as moderate. Captopril-hydrochlorothiazide and Toremifene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thiazides reduce urinary calcium excretion, and toremifene can cause hypercalcemia, particularly in patients with bone metastases. Combined use may raise serum calcium further.
How serious is the interaction between Captopril-hydrochlorothiazide and Toremifene?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum calcium during the first weeks of therapy and consider an alternative to the thiazide if hypercalcemia develops.
What other medicines interact with Captopril-hydrochlorothiazide?
MediHelp also lists interactions of Captopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sacubitril / valsartan. The full list is on the Captopril-hydrochlorothiazide page.
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