Drug interactions
Carbamazepine + Crofelemer
Severity: Minor
Carbamazepine and Crofelemer: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Crofelemer is minimally absorbed and inhibits CYP3A4 mainly in the gut at expected concentrations. Any increase in carbamazepine exposure is unlikely to be clinically relevant.
What this interaction means in plain words
Carbamazepine and Crofelemer have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Carbamazepine belongs to Central Nervous System; Crofelemer belongs to Gastrointestinal Tract.
Why it happens
Possible intestinal CYP3A4 inhibition by crofelemer, with minimal systemic effect.
What to do
No action beyond awareness; monitor for carbamazepine toxicity if symptoms arise.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Carbamazepine
- Artemether / lumefantrine + Carbamazepine Contraindicated
- Cabotegravir + Carbamazepine Contraindicated
- Carbamazepine + Delamanid Contraindicated
- Carbamazepine + Dienogest / estradiol valerate Contraindicated
- Carbamazepine + Doravirine Contraindicated
- Carbamazepine + Elbasvir / grazoprevir Contraindicated
Other interactions of Crofelemer
- Crofelemer + Ergotamine Moderate
- Alfuzosin + Crofelemer Minor
- Amiodarone + Crofelemer Minor
- Apixaban + Crofelemer Minor
- Aprepitant + Crofelemer Minor
- Armodafinil + Crofelemer Minor
Frequently asked questions
Can I take Carbamazepine with Crofelemer?
MediHelp rates the interaction as minor. Carbamazepine and Crofelemer have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Crofelemer is minimally absorbed and inhibits CYP3A4 mainly in the gut at expected concentrations. Any increase in carbamazepine exposure is unlikely to be clinically relevant.
How serious is the interaction between Carbamazepine and Crofelemer?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No action beyond awareness; monitor for carbamazepine toxicity if symptoms arise.
What other medicines interact with Carbamazepine?
MediHelp also lists interactions of Carbamazepine with, for example, Artemether / lumefantrine, Cabotegravir, Delamanid. The full list is on the Carbamazepine page.
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