Drug interactions
Carbamazepine + Dupilumab
Severity: Minor
Carbamazepine and Dupilumab: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dupilumab may reverse cytokine-mediated suppression of CYP450 enzymes in patients with chronic type 2 inflammation. This could change the clearance of CYP substrates such as carbamazepine, which has a narrow therapeutic index. The effect is theoretical and probably small.
What this interaction means in plain words
Carbamazepine and Dupilumab have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Carbamazepine belongs to Central Nervous System; Dupilumab belongs to Respiratory.
Why it happens
Normalization of cytokine-suppressed CYP450 expression may alter the metabolism of carbamazepine.
What to do
Consider checking carbamazepine concentrations and clinical response when dupilumab is started or stopped. Adjust the carbamazepine dose only if levels change.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Carbamazepine
- Artemether / lumefantrine + Carbamazepine Contraindicated
- Cabotegravir + Carbamazepine Contraindicated
- Carbamazepine + Delamanid Contraindicated
- Carbamazepine + Dienogest / estradiol valerate Contraindicated
- Carbamazepine + Doravirine Contraindicated
- Carbamazepine + Elbasvir / grazoprevir Contraindicated
Other interactions of Dupilumab
- Dupilumab + Smallpox vaccine live Major
- Adenovirus types 4 and 7 live + Dupilumab Moderate
- Bcg vaccine live + Dupilumab Moderate
- Cyclosporine + Dupilumab Moderate
- Disopyramide + Dupilumab Moderate
- Dupilumab + Fosphenytoin Moderate
Frequently asked questions
Can I take Carbamazepine with Dupilumab?
MediHelp rates the interaction as minor. Carbamazepine and Dupilumab have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Dupilumab may reverse cytokine-mediated suppression of CYP450 enzymes in patients with chronic type 2 inflammation. This could change the clearance of CYP substrates such as carbamazepine, which has a narrow therapeutic index. The effect is theoretical and probably small.
How serious is the interaction between Carbamazepine and Dupilumab?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider checking carbamazepine concentrations and clinical response when dupilumab is started or stopped. Adjust the carbamazepine dose only if levels change.
What other medicines interact with Carbamazepine?
MediHelp also lists interactions of Carbamazepine with, for example, Artemether / lumefantrine, Cabotegravir, Delamanid. The full list is on the Carbamazepine page.
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