Drug interactions
Carbamazepine + Estradiol
Severity: Moderate
Carbamazepine and Estradiol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbamazepine can reduce estradiol concentrations, which may lead to recurrence of menopausal symptoms or inadequate hormone replacement. In women using estrogen for contraception or endometrial protection, efficacy may be reduced.
What this interaction means in plain words
Carbamazepine and Estradiol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carbamazepine belongs to Central Nervous System; Estradiol belongs to Endocrine.
Why it happens
Carbamazepine induces CYP3A4 and increases estradiol metabolism, and may increase sex hormone-binding globulin.
What to do
Monitor symptom control and consider a higher estradiol dose or a non-oral route. For contraception use a non-inducer-sensitive method such as an intrauterine device.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Carbamazepine and Estradiol, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Carbamazepine
- Artemether / lumefantrine + Carbamazepine Contraindicated
- Cabotegravir + Carbamazepine Contraindicated
- Carbamazepine + Delamanid Contraindicated
- Carbamazepine + Dienogest / estradiol valerate Contraindicated
- Carbamazepine + Doravirine Contraindicated
- Carbamazepine + Elbasvir / grazoprevir Contraindicated
Other interactions of Estradiol
- Anastrozole + Estradiol Contraindicated
- Estradiol + Fezolinetant Contraindicated
- Estradiol + Ospemifene Contraindicated
- Antithrombin alfa + Estradiol Major
- Antithrombin iii + Estradiol Major
- Estradiol + Exemestane Major
Frequently asked questions
Can I take Carbamazepine with Estradiol?
MediHelp rates the interaction as moderate. Carbamazepine and Estradiol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Carbamazepine can reduce estradiol concentrations, which may lead to recurrence of menopausal symptoms or inadequate hormone replacement. In women using estrogen for contraception or endometrial protection, efficacy may be reduced.
How serious is the interaction between Carbamazepine and Estradiol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor symptom control and consider a higher estradiol dose or a non-oral route. For contraception use a non-inducer-sensitive method such as an intrauterine device.
What other medicines interact with Carbamazepine?
MediHelp also lists interactions of Carbamazepine with, for example, Artemether / lumefantrine, Cabotegravir, Delamanid. The full list is on the Carbamazepine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
