Drug interactions
Carbamazepine + Hydrochlorothiazide-irbesartan
Severity: Moderate
Carbamazepine and Hydrochlorothiazide-irbesartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both carbamazepine and thiazide diuretics can cause hyponatremia, and using them together increases the chance of clinically significant sodium depletion. Symptoms include headache, confusion, nausea, falls and seizures.
What this interaction means in plain words
Carbamazepine and Hydrochlorothiazide-irbesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carbamazepine belongs to Central Nervous System; Hydrochlorothiazide-irbesartan belongs to Cardiovascular.
Why it happens
Additive effects: carbamazepine enhances antidiuretic hormone action while the thiazide increases renal sodium loss.
What to do
Check serum sodium at baseline and periodically, especially in older adults and in the first weeks of therapy. Stop or replace the diuretic if sodium falls significantly or symptoms appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-irbesartan
- Aliskiren + Hydrochlorothiazide-irbesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-irbesartan Contraindicated
- Hydrochlorothiazide-irbesartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-irbesartan Major
- Amifostine + Hydrochlorothiazide-irbesartan Major
- Amiloride + Hydrochlorothiazide-irbesartan Major
Other interactions of Carbamazepine
- Artemether / lumefantrine + Carbamazepine Contraindicated
- Cabotegravir + Carbamazepine Contraindicated
- Carbamazepine + Delamanid Contraindicated
- Carbamazepine + Dienogest / estradiol valerate Contraindicated
- Carbamazepine + Doravirine Contraindicated
- Carbamazepine + Elbasvir / grazoprevir Contraindicated
Frequently asked questions
Can I take Carbamazepine with Hydrochlorothiazide-irbesartan?
MediHelp rates the interaction as moderate. Carbamazepine and Hydrochlorothiazide-irbesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both carbamazepine and thiazide diuretics can cause hyponatremia, and using them together increases the chance of clinically significant sodium depletion. Symptoms include headache, confusion, nausea, falls and seizures.
How serious is the interaction between Carbamazepine and Hydrochlorothiazide-irbesartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum sodium at baseline and periodically, especially in older adults and in the first weeks of therapy. Stop or replace the diuretic if sodium falls significantly or symptoms appear.
What other medicines interact with Hydrochlorothiazide-irbesartan?
MediHelp also lists interactions of Hydrochlorothiazide-irbesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-irbesartan page.
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