Drug interactions
Carbamazepine + Linagliptin
Severity: Moderate
Carbamazepine and Linagliptin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbamazepine can reduce linagliptin exposure and may weaken its glucose-lowering effect. Labeling advises alternative treatment when linagliptin is used with strong inducers.
What this interaction means in plain words
Carbamazepine and Linagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carbamazepine belongs to Central Nervous System; Linagliptin belongs to Endocrine.
Why it happens
Carbamazepine induces CYP3A4 and P-glycoprotein, increasing linagliptin clearance.
What to do
Consider an alternative antidiabetic agent. If the combination continues, monitor glycemic control.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Carbamazepine
- Artemether / lumefantrine + Carbamazepine Contraindicated
- Cabotegravir + Carbamazepine Contraindicated
- Carbamazepine + Delamanid Contraindicated
- Carbamazepine + Dienogest / estradiol valerate Contraindicated
- Carbamazepine + Doravirine Contraindicated
- Carbamazepine + Elbasvir / grazoprevir Contraindicated
Other interactions of Linagliptin
- Alogliptin-pioglitazone + Linagliptin Moderate
- Amlodipine-benazepril + Linagliptin Moderate
- Amobarbital + Linagliptin Moderate
- Apalutamide + Linagliptin Moderate
- Benazepril + Linagliptin Moderate
- Bexarotene + Linagliptin Moderate
Frequently asked questions
Can I take Carbamazepine with Linagliptin?
MediHelp rates the interaction as moderate. Carbamazepine and Linagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Carbamazepine can reduce linagliptin exposure and may weaken its glucose-lowering effect. Labeling advises alternative treatment when linagliptin is used with strong inducers.
How serious is the interaction between Carbamazepine and Linagliptin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider an alternative antidiabetic agent. If the combination continues, monitor glycemic control.
What other medicines interact with Carbamazepine?
MediHelp also lists interactions of Carbamazepine with, for example, Artemether / lumefantrine, Cabotegravir, Delamanid. The full list is on the Carbamazepine page.
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