Drug interactions
Carbamazepine + Rucaparib
Severity: Minor
Carbamazepine and Rucaparib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rucaparib is a weak inhibitor of CYP3A4 and may modestly raise carbamazepine levels. This could cause dizziness, ataxia or other carbamazepine toxicity in sensitive patients.
What this interaction means in plain words
Carbamazepine and Rucaparib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Carbamazepine belongs to Central Nervous System; Rucaparib belongs to Oncology.
Why it happens
Rucaparib weakly inhibits CYP3A4, reducing carbamazepine metabolism.
What to do
Monitor for carbamazepine adverse effects and check serum levels if symptoms occur. Adjust the carbamazepine dose as needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Carbamazepine
- Artemether / lumefantrine + Carbamazepine Contraindicated
- Cabotegravir + Carbamazepine Contraindicated
- Carbamazepine + Delamanid Contraindicated
- Carbamazepine + Dienogest / estradiol valerate Contraindicated
- Carbamazepine + Doravirine Contraindicated
- Carbamazepine + Elbasvir / grazoprevir Contraindicated
Other interactions of Rucaparib
- Cisapride + Rucaparib Major
- Ergotamine + Rucaparib Major
- Pimozide + Rucaparib Major
- Alfuzosin + Rucaparib Moderate
- Aripiprazole + Rucaparib Moderate
- Atorvastatin + Rucaparib Moderate
Frequently asked questions
Can I take Carbamazepine with Rucaparib?
MediHelp rates the interaction as minor. Carbamazepine and Rucaparib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Rucaparib is a weak inhibitor of CYP3A4 and may modestly raise carbamazepine levels. This could cause dizziness, ataxia or other carbamazepine toxicity in sensitive patients.
How serious is the interaction between Carbamazepine and Rucaparib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for carbamazepine adverse effects and check serum levels if symptoms occur. Adjust the carbamazepine dose as needed.
What other medicines interact with Carbamazepine?
MediHelp also lists interactions of Carbamazepine with, for example, Artemether / lumefantrine, Cabotegravir, Delamanid. The full list is on the Carbamazepine page.
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