Drug interactions
Carbamazepine + Stiripentol
Severity: Moderate
Carbamazepine and Stiripentol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbamazepine can lower stiripentol exposure, while stiripentol inhibits carbamazepine metabolism and raises its levels, causing toxicity. The net effect is hard to predict and both seizure control and adverse effects may be altered.
What this interaction means in plain words
Carbamazepine and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carbamazepine belongs to Central Nervous System; Stiripentol belongs to Central Nervous System.
Why it happens
Carbamazepine induces CYP3A4, CYP1A2 and CYP2C19 metabolism of stiripentol, while stiripentol inhibits CYP3A4 metabolism of carbamazepine.
What to do
Monitor carbamazepine serum levels and adjust the dose, and reduce carbamazepine if toxicity occurs. Assess seizure control and consider stiripentol dose adjustment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Carbamazepine
- Artemether / lumefantrine + Carbamazepine Contraindicated
- Cabotegravir + Carbamazepine Contraindicated
- Carbamazepine + Delamanid Contraindicated
- Carbamazepine + Dienogest / estradiol valerate Contraindicated
- Carbamazepine + Doravirine Contraindicated
- Carbamazepine + Elbasvir / grazoprevir Contraindicated
Other interactions of Stiripentol
Frequently asked questions
Can I take Carbamazepine with Stiripentol?
MediHelp rates the interaction as moderate. Carbamazepine and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Carbamazepine can lower stiripentol exposure, while stiripentol inhibits carbamazepine metabolism and raises its levels, causing toxicity. The net effect is hard to predict and both seizure control and adverse effects may be altered.
How serious is the interaction between Carbamazepine and Stiripentol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor carbamazepine serum levels and adjust the dose, and reduce carbamazepine if toxicity occurs. Assess seizure control and consider stiripentol dose adjustment.
What other medicines interact with Carbamazepine?
MediHelp also lists interactions of Carbamazepine with, for example, Artemether / lumefantrine, Cabotegravir, Delamanid. The full list is on the Carbamazepine page.
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