Drug interactions
Carbamazepine + Trimipramine
Severity: Moderate
Carbamazepine and Trimipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbamazepine induces hepatic enzymes and can lower trimipramine plasma concentrations, reducing antidepressant effect. Tricyclics may also raise carbamazepine levels in some patients, and carbamazepine is structurally similar to tricyclics.
What this interaction means in plain words
Carbamazepine and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carbamazepine belongs to Central Nervous System; Trimipramine belongs to Central Nervous System.
Why it happens
Induction of CYP3A4 and other CYP enzymes by carbamazepine increases trimipramine metabolism.
What to do
Monitor clinical response and consider trimipramine plasma level monitoring, with dose increases if needed. Check carbamazepine levels and watch for toxicity when the tricyclic is added or removed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trimipramine
- Disopyramide + Trimipramine Contraindicated
- Dofetilide + Trimipramine Contraindicated
- Ibutilide + Trimipramine Contraindicated
- Isocarboxazid + Trimipramine Contraindicated
- Pentamidine + Trimipramine Contraindicated
- Phenelzine + Trimipramine Contraindicated
Other interactions of Carbamazepine
- Artemether / lumefantrine + Carbamazepine Contraindicated
- Cabotegravir + Carbamazepine Contraindicated
- Carbamazepine + Delamanid Contraindicated
- Carbamazepine + Dienogest / estradiol valerate Contraindicated
- Carbamazepine + Doravirine Contraindicated
- Carbamazepine + Elbasvir / grazoprevir Contraindicated
Frequently asked questions
Can I take Carbamazepine with Trimipramine?
MediHelp rates the interaction as moderate. Carbamazepine and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Carbamazepine induces hepatic enzymes and can lower trimipramine plasma concentrations, reducing antidepressant effect. Tricyclics may also raise carbamazepine levels in some patients, and carbamazepine is structurally similar to tricyclics.
How serious is the interaction between Carbamazepine and Trimipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response and consider trimipramine plasma level monitoring, with dose increases if needed. Check carbamazepine levels and watch for toxicity when the tricyclic is added or removed.
What other medicines interact with Trimipramine?
MediHelp also lists interactions of Trimipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Trimipramine page.
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