Drug interactions
Carbamazepine + Vortioxetine
Severity: Moderate
Carbamazepine and Vortioxetine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbamazepine strongly induces hepatic metabolism and markedly lowers vortioxetine exposure. The antidepressant effect may be lost.
What this interaction means in plain words
Carbamazepine and Vortioxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carbamazepine belongs to Central Nervous System; Vortioxetine belongs to Central Nervous System.
Why it happens
Induction of CYP3A4 and other CYP enzymes increases vortioxetine clearance.
What to do
Monitor clinical response and consider raising the vortioxetine dose, within labeled maximums, if carbamazepine is continued. Reduce the dose back if carbamazepine is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vortioxetine
- Isocarboxazid + Vortioxetine Contraindicated
- Linezolid + Vortioxetine Contraindicated
- Methylene blue + Vortioxetine Contraindicated
- Phenelzine + Vortioxetine Contraindicated
- Rasagiline + Vortioxetine Contraindicated
- Selegiline transdermal + Vortioxetine Contraindicated
Other interactions of Carbamazepine
- Artemether / lumefantrine + Carbamazepine Contraindicated
- Cabotegravir + Carbamazepine Contraindicated
- Carbamazepine + Delamanid Contraindicated
- Carbamazepine + Dienogest / estradiol valerate Contraindicated
- Carbamazepine + Doravirine Contraindicated
- Carbamazepine + Elbasvir / grazoprevir Contraindicated
Frequently asked questions
Can I take Carbamazepine with Vortioxetine?
MediHelp rates the interaction as moderate. Carbamazepine and Vortioxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Carbamazepine strongly induces hepatic metabolism and markedly lowers vortioxetine exposure. The antidepressant effect may be lost.
How serious is the interaction between Carbamazepine and Vortioxetine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response and consider raising the vortioxetine dose, within labeled maximums, if carbamazepine is continued. Reduce the dose back if carbamazepine is stopped.
What other medicines interact with Vortioxetine?
MediHelp also lists interactions of Vortioxetine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Vortioxetine page.
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