Drug interactions
Carbidopa-levodopa + Solriamfetol
Severity: Moderate
Carbidopa-levodopa and Solriamfetol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Solriamfetol is a dopamine and norepinephrine reuptake inhibitor that raises blood pressure and heart rate. Levodopa increases dopaminergic and adrenergic activity, so the combination may lead to additive cardiovascular stimulation. Labeling advises caution with drugs that raise dopamine levels.
What this interaction means in plain words
Carbidopa-levodopa and Solriamfetol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carbidopa-levodopa belongs to Central Nervous System; Solriamfetol belongs to Central Nervous System.
Why it happens
Additive dopaminergic and noradrenergic effects from reuptake inhibition and increased dopamine precursor availability.
What to do
Monitor blood pressure and heart rate at initiation and after dose changes. Reduce the solriamfetol dose or stop it if hypertension or tachycardia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Carbidopa-levodopa
- Carbidopa-levodopa + Isocarboxazid Contraindicated
- Carbidopa-levodopa + Phenelzine Contraindicated
- Carbidopa-levodopa + Selegiline transdermal Contraindicated
- Carbidopa-levodopa + Tranylcypromine Contraindicated
- Amisulpride + Carbidopa-levodopa Major
- Asenapine + Carbidopa-levodopa Major
Other interactions of Solriamfetol
- Isocarboxazid + Solriamfetol Contraindicated
- Linezolid + Solriamfetol Contraindicated
- Phenelzine + Solriamfetol Contraindicated
- Procarbazine + Solriamfetol Contraindicated
- Rasagiline + Solriamfetol Contraindicated
- Safinamide + Solriamfetol Contraindicated
Frequently asked questions
Can I take Carbidopa-levodopa with Solriamfetol?
MediHelp rates the interaction as moderate. Carbidopa-levodopa and Solriamfetol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Solriamfetol is a dopamine and norepinephrine reuptake inhibitor that raises blood pressure and heart rate. Levodopa increases dopaminergic and adrenergic activity, so the combination may lead to additive cardiovascular stimulation. Labeling advises caution with drugs that raise dopamine levels.
How serious is the interaction between Carbidopa-levodopa and Solriamfetol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate at initiation and after dose changes. Reduce the solriamfetol dose or stop it if hypertension or tachycardia develops.
What other medicines interact with Carbidopa-levodopa?
MediHelp also lists interactions of Carbidopa-levodopa with, for example, Isocarboxazid, Phenelzine, Selegiline transdermal. The full list is on the Carbidopa-levodopa page.
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