Drug interactions
Carbinoxamine + Metoclopramide
Severity: Moderate
Carbinoxamine and Metoclopramide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbinoxamine is a sedating antihistamine and metoclopramide can cause drowsiness, so the combination may increase sedation and impair psychomotor performance. Its anticholinergic activity may also oppose the prokinetic action of metoclopramide.
What this interaction means in plain words
Carbinoxamine and Metoclopramide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carbinoxamine belongs to Respiratory; Metoclopramide belongs to Gastrointestinal Tract.
Why it happens
Additive CNS depression, with anticholinergic antagonism of metoclopramide's gastrointestinal prokinetic effect.
What to do
Monitor for sedation and reduced prokinetic response. Advise the patient against driving until the response is known.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metoclopramide
Other interactions of Carbinoxamine
- Alprazolam + Carbinoxamine Moderate
- Amisulpride + Carbinoxamine Moderate
- Amitriptyline + Carbinoxamine Moderate
- Amobarbital + Carbinoxamine Moderate
- Asenapine + Carbinoxamine Moderate
- Azelastine-fluticasone + Carbinoxamine Moderate
Frequently asked questions
Can I take Carbinoxamine with Metoclopramide?
MediHelp rates the interaction as moderate. Carbinoxamine and Metoclopramide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Carbinoxamine is a sedating antihistamine and metoclopramide can cause drowsiness, so the combination may increase sedation and impair psychomotor performance. Its anticholinergic activity may also oppose the prokinetic action of metoclopramide.
How serious is the interaction between Carbinoxamine and Metoclopramide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and reduced prokinetic response. Advise the patient against driving until the response is known.
What other medicines interact with Metoclopramide?
MediHelp also lists interactions of Metoclopramide with, for example, Amantadine, Amoxapine, Antipsychotics (e.g., haloperidol). The full list is on the Metoclopramide page.
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