Drug interactions
Carbinoxamine + Propofol
Severity: Minor
Carbinoxamine and Propofol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbinoxamine is a sedating first-generation antihistamine that can add to the sedative effect of propofol. Deeper sedation and slower recovery may result.
What this interaction means in plain words
Carbinoxamine and Propofol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Carbinoxamine belongs to Respiratory; Propofol belongs to Central Nervous System.
Why it happens
Additive CNS depression via central H1-receptor antagonism and GABA-A potentiation.
What to do
Titrate propofol to effect and monitor sedation depth and respiratory status. No routine dose change is needed beyond usual titration.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Propofol
Other interactions of Carbinoxamine
- Alprazolam + Carbinoxamine Moderate
- Amisulpride + Carbinoxamine Moderate
- Amitriptyline + Carbinoxamine Moderate
- Amobarbital + Carbinoxamine Moderate
- Asenapine + Carbinoxamine Moderate
- Azelastine-fluticasone + Carbinoxamine Moderate
Frequently asked questions
Can I take Carbinoxamine with Propofol?
MediHelp rates the interaction as minor. Carbinoxamine and Propofol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Carbinoxamine is a sedating first-generation antihistamine that can add to the sedative effect of propofol. Deeper sedation and slower recovery may result.
How serious is the interaction between Carbinoxamine and Propofol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate propofol to effect and monitor sedation depth and respiratory status. No routine dose change is needed beyond usual titration.
What other medicines interact with Propofol?
MediHelp also lists interactions of Propofol with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Propofol page.
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