Drug interactions
Carfilzomib + Danicopan
Severity: Minor
Carfilzomib and Danicopan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Danicopan inhibits P-glycoprotein and may increase exposure to P-gp substrates. Carfilzomib is eliminated mainly through extrahepatic peptidase metabolism, so the effect is probably small.
What this interaction means in plain words
Carfilzomib and Danicopan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Carfilzomib belongs to Oncology; Danicopan belongs to Miscellaneous.
Why it happens
Danicopan inhibits P-gp efflux, which may modestly raise carfilzomib concentrations.
What to do
No empirical dose adjustment is needed; watch for carfilzomib adverse effects such as dyspnea, hypertension and cytopenias.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Carfilzomib
- Carfilzomib + Etrasimod Major
- Carfilzomib + Ropeginterferon alfa 2b Major
- Carfilzomib + Dichlorphenamide Moderate
- Carfilzomib + Palifermin Moderate
- Carfilzomib + Ponesimod Moderate
- Carfilzomib + Siponimod Moderate
Other interactions of Danicopan
- Amiodarone + Danicopan Moderate
- Apixaban + Danicopan Moderate
- Atorvastatin + Danicopan Moderate
- Brentuximab + Danicopan Moderate
- Carvedilol + Danicopan Moderate
- Cladribine + Danicopan Moderate
Frequently asked questions
Can I take Carfilzomib with Danicopan?
MediHelp rates the interaction as minor. Carfilzomib and Danicopan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Danicopan inhibits P-glycoprotein and may increase exposure to P-gp substrates. Carfilzomib is eliminated mainly through extrahepatic peptidase metabolism, so the effect is probably small.
How serious is the interaction between Carfilzomib and Danicopan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical dose adjustment is needed; watch for carfilzomib adverse effects such as dyspnea, hypertension and cytopenias.
What other medicines interact with Carfilzomib?
MediHelp also lists interactions of Carfilzomib with, for example, Etrasimod, Ropeginterferon alfa 2b, Dichlorphenamide. The full list is on the Carfilzomib page.
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