Drug interactions
Carfilzomib + Fostamatinib
Severity: Minor
Carfilzomib and Fostamatinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The active metabolite of fostamatinib inhibits P-glycoprotein and can raise concentrations of P-gp substrates. Carfilzomib is a P-gp substrate but is cleared mainly by peptidases, so the impact is likely limited.
What this interaction means in plain words
Carfilzomib and Fostamatinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Carfilzomib belongs to Oncology; Fostamatinib belongs to Oncology.
Why it happens
Fostamatinib's active metabolite (R406) inhibits P-gp efflux, possibly increasing carfilzomib exposure.
What to do
No routine dose change is needed; monitor for carfilzomib adverse effects and reduce the dose if toxicity develops.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Carfilzomib
- Carfilzomib + Etrasimod Major
- Carfilzomib + Ropeginterferon alfa 2b Major
- Carfilzomib + Dichlorphenamide Moderate
- Carfilzomib + Palifermin Moderate
- Carfilzomib + Ponesimod Moderate
- Carfilzomib + Siponimod Moderate
Other interactions of Fostamatinib
- Colchicine + Fostamatinib Major
- Fostamatinib + Phenytoin Major
- Amobarbital + Fostamatinib Moderate
- Apalutamide + Fostamatinib Moderate
- Atorvastatin + Fostamatinib Moderate
- Bosentan + Fostamatinib Moderate
Frequently asked questions
Can I take Carfilzomib with Fostamatinib?
MediHelp rates the interaction as minor. Carfilzomib and Fostamatinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. The active metabolite of fostamatinib inhibits P-glycoprotein and can raise concentrations of P-gp substrates. Carfilzomib is a P-gp substrate but is cleared mainly by peptidases, so the impact is likely limited.
How serious is the interaction between Carfilzomib and Fostamatinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed; monitor for carfilzomib adverse effects and reduce the dose if toxicity develops.
What other medicines interact with Carfilzomib?
MediHelp also lists interactions of Carfilzomib with, for example, Etrasimod, Ropeginterferon alfa 2b, Dichlorphenamide. The full list is on the Carfilzomib page.
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