Drug interactions
Carfilzomib + Stiripentol
Severity: Minor
Carfilzomib and Stiripentol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stiripentol inhibits P-glycoprotein in vitro, and carfilzomib is a P-gp substrate, so exposure to carfilzomib could be raised. Because carfilzomib is cleared mainly by non-CYP, non-P-gp pathways, the clinical effect is probably small.
What this interaction means in plain words
Carfilzomib and Stiripentol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Carfilzomib belongs to Oncology; Stiripentol belongs to Central Nervous System.
Why it happens
Stiripentol inhibits P-gp efflux, which may modestly increase carfilzomib exposure.
What to do
No routine dose adjustment is needed; monitor for carfilzomib adverse effects and reduce the dose if toxicity appears.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Carfilzomib
- Carfilzomib + Etrasimod Major
- Carfilzomib + Ropeginterferon alfa 2b Major
- Carfilzomib + Dichlorphenamide Moderate
- Carfilzomib + Palifermin Moderate
- Carfilzomib + Ponesimod Moderate
- Carfilzomib + Siponimod Moderate
Other interactions of Stiripentol
Frequently asked questions
Can I take Carfilzomib with Stiripentol?
MediHelp rates the interaction as minor. Carfilzomib and Stiripentol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Stiripentol inhibits P-glycoprotein in vitro, and carfilzomib is a P-gp substrate, so exposure to carfilzomib could be raised. Because carfilzomib is cleared mainly by non-CYP, non-P-gp pathways, the clinical effect is probably small.
How serious is the interaction between Carfilzomib and Stiripentol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose adjustment is needed; monitor for carfilzomib adverse effects and reduce the dose if toxicity appears.
What other medicines interact with Carfilzomib?
MediHelp also lists interactions of Carfilzomib with, for example, Etrasimod, Ropeginterferon alfa 2b, Dichlorphenamide. The full list is on the Carfilzomib page.
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