Drug interactions
Cariprazine + Chlorpromazine
Severity: Moderate
Cariprazine and Chlorpromazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are antipsychotics with sedative and dopamine-blocking properties. Combining them can add to somnolence, orthostatic hypotension and extrapyramidal symptoms, with little evidence of added benefit.
What this interaction means in plain words
Cariprazine and Chlorpromazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cariprazine belongs to Central Nervous System; Chlorpromazine belongs to Central Nervous System.
Why it happens
Additive dopamine receptor antagonism and CNS depression.
What to do
Avoid antipsychotic polypharmacy unless clearly justified. If used, monitor for sedation, hypotension and movement disorders.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorpromazine
- Chlorpromazine + Dofetilide Contraindicated
- Chlorpromazine + Dronedarone Contraindicated
- Chlorpromazine + Droperidol Contraindicated
- Chlorpromazine + Ibutilide Contraindicated
- Chlorpromazine + Metrizamide Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
Other interactions of Cariprazine
Frequently asked questions
Can I take Cariprazine with Chlorpromazine?
MediHelp rates the interaction as moderate. Cariprazine and Chlorpromazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both are antipsychotics with sedative and dopamine-blocking properties. Combining them can add to somnolence, orthostatic hypotension and extrapyramidal symptoms, with little evidence of added benefit.
How serious is the interaction between Cariprazine and Chlorpromazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid antipsychotic polypharmacy unless clearly justified. If used, monitor for sedation, hypotension and movement disorders.
What other medicines interact with Chlorpromazine?
MediHelp also lists interactions of Chlorpromazine with, for example, Dofetilide, Dronedarone, Droperidol. The full list is on the Chlorpromazine page.
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