Drug interactions
Cariprazine + Metoclopramide
Severity: Major
Cariprazine and Metoclopramide: major interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cariprazine is a D2/D3 partial agonist, and combining it with metoclopramide increases the risk of extrapyramidal symptoms, akathisia, tardive dyskinesia and neuroleptic malignant syndrome. Cariprazine has a long half-life, so effects may persist after discontinuation.
What this interaction means in plain words
Cariprazine and Metoclopramide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cariprazine belongs to Central Nervous System; Metoclopramide belongs to Gastrointestinal Tract.
Why it happens
Additive dopamine receptor antagonism or modulation causing extrapyramidal toxicity.
What to do
Avoid the combination and use a non-dopamine-blocking antiemetic. If it cannot be avoided, monitor for akathisia, rigidity and abnormal movements.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Metoclopramide
Other interactions of Cariprazine
Frequently asked questions
Can I take Cariprazine with Metoclopramide?
MediHelp rates the interaction as major. Cariprazine and Metoclopramide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cariprazine is a D2/D3 partial agonist, and combining it with metoclopramide increases the risk of extrapyramidal symptoms, akathisia, tardive dyskinesia and neuroleptic malignant syndrome. Cariprazine has a long half-life, so effects may persist after discontinuation.
How serious is the interaction between Cariprazine and Metoclopramide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use a non-dopamine-blocking antiemetic. If it cannot be avoided, monitor for akathisia, rigidity and abnormal movements.
What other medicines interact with Metoclopramide?
MediHelp also lists interactions of Metoclopramide with, for example, Amantadine, Amoxapine, Antipsychotics (e.g., haloperidol). The full list is on the Metoclopramide page.
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