Drug interactions
Cariprazine + Posaconazole
Severity: Major
Cariprazine and Posaconazole: major interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Posaconazole raises exposure to cariprazine and its active metabolites, increasing the risk of akathisia, extrapyramidal symptoms and sedation. The long half-life of cariprazine's active metabolites means effects persist after the inhibitor is stopped.
What this interaction means in plain words
Cariprazine and Posaconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cariprazine belongs to Central Nervous System; Posaconazole belongs to Anti Fungals.
Why it happens
Posaconazole inhibits CYP3A4, which is the main metabolic pathway of cariprazine.
What to do
Reduce the cariprazine dose according to labeling when a strong CYP3A4 inhibitor is started, and monitor for extrapyramidal symptoms. Adjust the dose again when posaconazole is withdrawn.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Other interactions of Cariprazine
Frequently asked questions
Can I take Cariprazine with Posaconazole?
MediHelp rates the interaction as major. Cariprazine and Posaconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Posaconazole raises exposure to cariprazine and its active metabolites, increasing the risk of akathisia, extrapyramidal symptoms and sedation. The long half-life of cariprazine's active metabolites means effects persist after the inhibitor is stopped.
How serious is the interaction between Cariprazine and Posaconazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce the cariprazine dose according to labeling when a strong CYP3A4 inhibitor is started, and monitor for extrapyramidal symptoms. Adjust the dose again when posaconazole is withdrawn.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
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