Drug interactions
Cariprazine + Prochlorperazine
Severity: Moderate
Cariprazine and Prochlorperazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are dopamine antagonists or partial agonists with sedative properties. Combining them may increase drowsiness, extrapyramidal symptoms and, rarely, neuroleptic malignant syndrome. Orthostatic hypotension may also be additive.
What this interaction means in plain words
Cariprazine and Prochlorperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cariprazine belongs to Central Nervous System; Prochlorperazine belongs to Central Nervous System.
Why it happens
Additive dopamine D2 receptor blockade and additive CNS depressant effects.
What to do
Avoid concurrent long-term use where possible; if used together, monitor for extrapyramidal symptoms, sedation and orthostatic hypotension. Use the lowest effective doses.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Prochlorperazine
- Dronedarone + Prochlorperazine Contraindicated
- Ibutilide + Prochlorperazine Contraindicated
- Nilotinib + Prochlorperazine Contraindicated
- Pimozide + Prochlorperazine Contraindicated
- Prochlorperazine + Thioridazine Contraindicated
- Amiodarone + Prochlorperazine Major
Other interactions of Cariprazine
Frequently asked questions
Can I take Cariprazine with Prochlorperazine?
MediHelp rates the interaction as moderate. Cariprazine and Prochlorperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs are dopamine antagonists or partial agonists with sedative properties. Combining them may increase drowsiness, extrapyramidal symptoms and, rarely, neuroleptic malignant syndrome. Orthostatic hypotension may also be additive.
How serious is the interaction between Cariprazine and Prochlorperazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent long-term use where possible; if used together, monitor for extrapyramidal symptoms, sedation and orthostatic hypotension. Use the lowest effective doses.
What other medicines interact with Prochlorperazine?
MediHelp also lists interactions of Prochlorperazine with, for example, Dronedarone, Ibutilide, Nilotinib. The full list is on the Prochlorperazine page.
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