Drug interactions
Cariprazine + Pyrilamine
Severity: Minor
Cariprazine and Pyrilamine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pyrilamine is a first-generation sedating antihistamine. Together with cariprazine it can increase drowsiness, impaired concentration and fall risk.
What this interaction means in plain words
Cariprazine and Pyrilamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cariprazine belongs to Central Nervous System; Pyrilamine belongs to Respiratory.
Why it happens
Additive central nervous system depression.
What to do
Counsel patients about drowsiness and avoid driving until response is known; consider a non-sedating antihistamine if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cariprazine
Other interactions of Pyrilamine
- Fentanyl + Pyrilamine Moderate
- Levetiracetam + Pyrilamine Moderate
- Amisulpride + Pyrilamine Minor
- Asenapine + Pyrilamine Minor
- Brexpiprazole + Pyrilamine Minor
- Brimonidine + Pyrilamine Minor
Frequently asked questions
Can I take Cariprazine with Pyrilamine?
MediHelp rates the interaction as minor. Cariprazine and Pyrilamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Pyrilamine is a first-generation sedating antihistamine. Together with cariprazine it can increase drowsiness, impaired concentration and fall risk.
How serious is the interaction between Cariprazine and Pyrilamine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients about drowsiness and avoid driving until response is known; consider a non-sedating antihistamine if needed.
What other medicines interact with Cariprazine?
MediHelp also lists interactions of Cariprazine with, for example, Alfentanil, Amisulpride, Amobarbital. The full list is on the Cariprazine page.
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