Drug interactions
Cariprazine + Vilazodone
Severity: Moderate
Cariprazine and Vilazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vilazodone adds serotonergic activity to cariprazine, a dopamine D2/D3 partial agonist antipsychotic with serotonin receptor effects. Serotonin syndrome or neuroleptic malignant syndrome is possible but uncommon.
What this interaction means in plain words
Cariprazine and Vilazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cariprazine belongs to Central Nervous System; Vilazodone belongs to Central Nervous System.
Why it happens
Additive serotonergic effects with dopamine receptor modulation, a pharmacodynamic interaction.
What to do
Monitor for agitation, tremor, clonus, hyperthermia, rigidity and autonomic instability when initiating or titrating either drug. Discontinue the agents and give supportive care if toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vilazodone
- Isocarboxazid + Vilazodone Contraindicated
- Methylene blue + Vilazodone Contraindicated
- Phenelzine + Vilazodone Contraindicated
- Rasagiline + Vilazodone Contraindicated
- Selegiline transdermal + Vilazodone Contraindicated
- Selegiline + Vilazodone Contraindicated
Other interactions of Cariprazine
Frequently asked questions
Can I take Cariprazine with Vilazodone?
MediHelp rates the interaction as moderate. Cariprazine and Vilazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vilazodone adds serotonergic activity to cariprazine, a dopamine D2/D3 partial agonist antipsychotic with serotonin receptor effects. Serotonin syndrome or neuroleptic malignant syndrome is possible but uncommon.
How serious is the interaction between Cariprazine and Vilazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for agitation, tremor, clonus, hyperthermia, rigidity and autonomic instability when initiating or titrating either drug. Discontinue the agents and give supportive care if toxicity develops.
What other medicines interact with Vilazodone?
MediHelp also lists interactions of Vilazodone with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Vilazodone page.
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