Drug interactions
Caspofungin + Eluxadoline
Severity: Minor
Caspofungin and Eluxadoline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eluxadoline is an OATP1B1 substrate, and OATP1B1 inhibitors increase its exposure. Caspofungin is not a well-established OATP1B1 inhibitor, so the interaction is largely theoretical.
What this interaction means in plain words
Caspofungin and Eluxadoline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Caspofungin belongs to Anti Fungals; Eluxadoline belongs to Gastrointestinal Tract.
Why it happens
Possible OATP1B1 inhibition by caspofungin reducing hepatic uptake of eluxadoline; not well established.
What to do
Monitor for eluxadoline adverse effects such as constipation, nausea and abdominal pain. Consider the 75 mg twice-daily dose if a clinically relevant OATP1B1 inhibitor is confirmed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Caspofungin
- Apalutamide + Caspofungin Moderate
- Carbamazepine + Caspofungin Moderate
- Caspofungin + Cyclosporin Moderate
- Caspofungin + Dexamethasone Moderate
- Caspofungin + Efavirenz Moderate
- Caspofungin + Fosphenytoin Moderate
Other interactions of Eluxadoline
Frequently asked questions
Can I take Caspofungin with Eluxadoline?
MediHelp rates the interaction as minor. Caspofungin and Eluxadoline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Eluxadoline is an OATP1B1 substrate, and OATP1B1 inhibitors increase its exposure. Caspofungin is not a well-established OATP1B1 inhibitor, so the interaction is largely theoretical.
How serious is the interaction between Caspofungin and Eluxadoline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for eluxadoline adverse effects such as constipation, nausea and abdominal pain. Consider the 75 mg twice-daily dose if a clinically relevant OATP1B1 inhibitor is confirmed.
What other medicines interact with Caspofungin?
MediHelp also lists interactions of Caspofungin with, for example, Apalutamide, Carbamazepine, Cyclosporin. The full list is on the Caspofungin page.
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