Drug interactions
Caspofungin + Letermovir
Severity: Minor
Caspofungin and Letermovir: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Caspofungin is an OATP1B1/3 substrate, and letermovir inhibits OATP1B1/3, so caspofungin exposure may increase modestly. In clinical use together, no dose adjustment was required in letermovir trials.
What this interaction means in plain words
Caspofungin and Letermovir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Caspofungin belongs to Anti Fungals; Letermovir belongs to Anti Virals.
Why it happens
Letermovir inhibition of OATP1B1/3 hepatic uptake may raise caspofungin concentrations.
What to do
No dose adjustment is generally required; monitor liver enzymes during combined therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Caspofungin
- Apalutamide + Caspofungin Moderate
- Carbamazepine + Caspofungin Moderate
- Caspofungin + Cyclosporin Moderate
- Caspofungin + Dexamethasone Moderate
- Caspofungin + Efavirenz Moderate
- Caspofungin + Fosphenytoin Moderate
Other interactions of Letermovir
- Ergotamine + Letermovir Contraindicated
- Letermovir + Pimozide Contraindicated
- Apalutamide + Letermovir Major
- Atorvastatin + Letermovir Major
- Carbamazepine + Letermovir Major
- Colchicine + Letermovir Major
Frequently asked questions
Can I take Caspofungin with Letermovir?
MediHelp rates the interaction as minor. Caspofungin and Letermovir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Caspofungin is an OATP1B1/3 substrate, and letermovir inhibits OATP1B1/3, so caspofungin exposure may increase modestly. In clinical use together, no dose adjustment was required in letermovir trials.
How serious is the interaction between Caspofungin and Letermovir?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is generally required; monitor liver enzymes during combined therapy.
What other medicines interact with Caspofungin?
MediHelp also lists interactions of Caspofungin with, for example, Apalutamide, Carbamazepine, Cyclosporin. The full list is on the Caspofungin page.
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