Drug interactions
Caspofungin + Tacrolimus
Severity: Minor
Caspofungin and Tacrolimus: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Caspofungin may modestly lower tacrolimus blood concentrations in some patients. Loss of immunosuppression is a concern in transplant recipients.
What this interaction means in plain words
Caspofungin and Tacrolimus have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Caspofungin belongs to Anti Fungals; Tacrolimus belongs to Miscellaneous.
Why it happens
The mechanism is not well established.
What to do
Monitor tacrolimus trough concentrations when starting or stopping caspofungin and adjust the tacrolimus dose as needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Caspofungin
- Apalutamide + Caspofungin Moderate
- Carbamazepine + Caspofungin Moderate
- Caspofungin + Cyclosporin Moderate
- Caspofungin + Dexamethasone Moderate
- Caspofungin + Efavirenz Moderate
- Caspofungin + Fosphenytoin Moderate
Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Frequently asked questions
Can I take Caspofungin with Tacrolimus?
MediHelp rates the interaction as minor. Caspofungin and Tacrolimus have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Caspofungin may modestly lower tacrolimus blood concentrations in some patients. Loss of immunosuppression is a concern in transplant recipients.
How serious is the interaction between Caspofungin and Tacrolimus?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor tacrolimus trough concentrations when starting or stopping caspofungin and adjust the tacrolimus dose as needed.
What other medicines interact with Caspofungin?
MediHelp also lists interactions of Caspofungin with, for example, Apalutamide, Carbamazepine, Cyclosporin. The full list is on the Caspofungin page.
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