Drug interactions
Cefdinir + Plazomicin
Severity: Minor
Cefdinir and Plazomicin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Plazomicin is nephrotoxic and ototoxic, and cephalosporins have been reported to add to aminoglycoside kidney injury. Oral cefdinir has limited nephrotoxic potential, so the added risk is small but the aminoglycoside risk remains.
What this interaction means in plain words
Cefdinir and Plazomicin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cefdinir belongs to Anti Bacterial; Plazomicin belongs to Anti Bacterial.
Why it happens
Possible additive nephrotoxicity; the mechanism is not well established for cefdinir.
What to do
Monitor serum creatinine throughout plazomicin therapy and adjust the dose per renal function and drug levels.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cefdinir
- Aluminum hydroxide + Cefdinir Moderate
- Cefdinir + Cholera vaccine Moderate
- Cefdinir + Famotidine Moderate
- Cefdinir + Gentamicin Moderate
- Cefdinir + Microbiota Moderate
- Cefdinir + Nizatidine Moderate
Other interactions of Plazomicin
- Cefaclor + Plazomicin Moderate
- Cefadroxil + Plazomicin Moderate
- Cefalexin + Plazomicin Moderate
- Cefazolin + Plazomicin Moderate
- Cefditoren + Plazomicin Moderate
- Cefepime + Plazomicin Moderate
Frequently asked questions
Can I take Cefdinir with Plazomicin?
MediHelp rates the interaction as minor. Cefdinir and Plazomicin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Plazomicin is nephrotoxic and ototoxic, and cephalosporins have been reported to add to aminoglycoside kidney injury. Oral cefdinir has limited nephrotoxic potential, so the added risk is small but the aminoglycoside risk remains.
How serious is the interaction between Cefdinir and Plazomicin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine throughout plazomicin therapy and adjust the dose per renal function and drug levels.
What other medicines interact with Cefdinir?
MediHelp also lists interactions of Cefdinir with, for example, Aluminum hydroxide, Cholera vaccine, Famotidine. The full list is on the Cefdinir page.
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