Drug interactions
Cefpirome + Chloramphenicol
Severity: Minor
Cefpirome and Chloramphenicol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bacteriostatic antibiotics such as chloramphenicol may antagonize bactericidal beta-lactams in laboratory studies. Clinical evidence of reduced efficacy is limited and inconsistent.
What this interaction means in plain words
Cefpirome and Chloramphenicol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cefpirome belongs to Anti Bacterial; Chloramphenicol belongs to Anti Bacterial.
Why it happens
Bacteriostatic suppression of bacterial growth may reduce the activity of cell-wall-active beta-lactams, which depend on bacterial replication.
What to do
Avoid the combination in severe infections such as meningitis or endocarditis where bactericidal activity is essential. Otherwise use only if clearly indicated and monitor clinical response.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Cefpirome and Chloramphenicol, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Chloramphenicol
Other interactions of Cefpirome
- Amikacin + Cefpirome Moderate
- Bupropion-naltrexone + Cefpirome Moderate
- Bupropion + Cefpirome Moderate
- Cefpirome + Dexamethasone-tobramycin Moderate
- Cefpirome + Gentamicin Moderate
- Cefpirome + Streptomycin Moderate
Frequently asked questions
Can I take Cefpirome with Chloramphenicol?
MediHelp rates the interaction as minor. Cefpirome and Chloramphenicol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Bacteriostatic antibiotics such as chloramphenicol may antagonize bactericidal beta-lactams in laboratory studies. Clinical evidence of reduced efficacy is limited and inconsistent.
How serious is the interaction between Cefpirome and Chloramphenicol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination in severe infections such as meningitis or endocarditis where bactericidal activity is essential. Otherwise use only if clearly indicated and monitor clinical response.
What other medicines interact with Chloramphenicol?
MediHelp also lists interactions of Chloramphenicol with, for example, Adagrasib, Avapritinib, Bcg vaccine live. The full list is on the Chloramphenicol page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
