Drug interactions
Cefpirome + Ketoprofen
Severity: Minor
Cefpirome and Ketoprofen: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cefpirome is a cephalosporin eliminated renally, and ketoprofen is an organic anion also cleared by tubular secretion. Competition could theoretically increase exposure to either drug, but a meaningful clinical effect has not been demonstrated.
What this interaction means in plain words
Cefpirome and Ketoprofen have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cefpirome belongs to Anti Bacterial; Ketoprofen belongs to Musculoskeletal.
Why it happens
Theoretical competition for renal tubular anion secretion.
What to do
No routine adjustment is required. In renal impairment, monitor renal function and adjust the cefpirome dose according to creatinine clearance.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ketoprofen
- Ketoprofen + Ketorolac Contraindicated
- Ketoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Ketoprofen Major
- Acemetacin + Ketoprofen Major
- Acetylsalicylic acid + Ketoprofen Major
- Alteplase + Ketoprofen Major
Other interactions of Cefpirome
- Amikacin + Cefpirome Moderate
- Bupropion-naltrexone + Cefpirome Moderate
- Bupropion + Cefpirome Moderate
- Cefpirome + Dexamethasone-tobramycin Moderate
- Cefpirome + Gentamicin Moderate
- Cefpirome + Streptomycin Moderate
Frequently asked questions
Can I take Cefpirome with Ketoprofen?
MediHelp rates the interaction as minor. Cefpirome and Ketoprofen have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cefpirome is a cephalosporin eliminated renally, and ketoprofen is an organic anion also cleared by tubular secretion. Competition could theoretically increase exposure to either drug, but a meaningful clinical effect has not been demonstrated.
How serious is the interaction between Cefpirome and Ketoprofen?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is required. In renal impairment, monitor renal function and adjust the cefpirome dose according to creatinine clearance.
What other medicines interact with Ketoprofen?
MediHelp also lists interactions of Ketoprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Ketoprofen page.
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