Drug interactions
Cefpirome + Neomycin
Severity: Minor
Cefpirome and Neomycin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral neomycin is poorly absorbed, so systemic aminoglycoside exposure is usually small. Cefpirome is a parenteral cephalosporin that is renally cleared and has low intrinsic nephrotoxicity. Additive injury to the kidney or ear is unlikely unless neomycin is absorbed.
What this interaction means in plain words
Cefpirome and Neomycin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cefpirome belongs to Anti Bacterial; Neomycin belongs to Anti Bacterial.
Why it happens
Theoretical additive nephrotoxicity and ototoxicity that requires systemic aminoglycoside absorption, which is minimal with oral neomycin.
What to do
No routine action is needed when renal function is normal. Monitor serum creatinine in patients with renal impairment or prolonged neomycin use.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Neomycin
- Amikacin + Neomycin Major
- Amphotericin b deoxycholate + Neomycin Major
- Capreomycin + Neomycin Major
- Cidofovir + Neomycin Major
- Colistin + Neomycin Major
- Ethacrynic acid + Neomycin Major
Other interactions of Cefpirome
- Amikacin + Cefpirome Moderate
- Bupropion-naltrexone + Cefpirome Moderate
- Bupropion + Cefpirome Moderate
- Cefpirome + Dexamethasone-tobramycin Moderate
- Cefpirome + Gentamicin Moderate
- Cefpirome + Streptomycin Moderate
Frequently asked questions
Can I take Cefpirome with Neomycin?
MediHelp rates the interaction as minor. Cefpirome and Neomycin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Oral neomycin is poorly absorbed, so systemic aminoglycoside exposure is usually small. Cefpirome is a parenteral cephalosporin that is renally cleared and has low intrinsic nephrotoxicity. Additive injury to the kidney or ear is unlikely unless neomycin is absorbed.
How serious is the interaction between Cefpirome and Neomycin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action is needed when renal function is normal. Monitor serum creatinine in patients with renal impairment or prolonged neomycin use.
What other medicines interact with Neomycin?
MediHelp also lists interactions of Neomycin with, for example, Amikacin, Amphotericin b deoxycholate, Capreomycin. The full list is on the Neomycin page.
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